Combined Biological and Modeling Approach of Hematopoiesis: From Native to Stressed Erythropoiesis

We developed here a new mathematical modelling approach which reconciliates native and stress hematopoiesis, focused on hematopoietic stem progenitor compartments. first proposed an erythropoiesis model leaning minimum of 6 cell-amplification compartments, able to reproduce erythropoiesis. A phenylhydrazine-induced hemolytic was next applied, and in vivo data were used estimate parameters through optimized algorithm integrated regulatory processes. reduction all cell compartments observed, due drastic differentiation without proliferation during 7 days, followed by huge in including long-term cells, before returning normal values. The 6-compartment applied complexified integrating Thus, regulation hematopoiesis appears dispensable but mandatory for hematopoiesis. In conclusion this multi-step time-dependent immature opens opportunities understand development or pathological